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黄连素药性与功效刍议
作者：张玉佩 韩莉 杨钦河 孔怡琳
来源：《中国医药科学》2012年第21期
[摘要] 黄连素作为黄连的主要单体活性成分，其与黄连在性味、功效和主治病证上具有一致性，尤其在湿热证的防治研究和临床应用中疗效确切。黄连素清热燥湿属性与湿热证关系密切，其防治原则是临床上治疗高血压、高血糖和脂质代谢紊乱等代谢综合征症候群的中医理论基础。本文以黄连素临床应用现状为依据，探讨黄连素清热燥湿属性与湿热证之间的内在关系，为厘清黄连素的药性和功效提供中医理论依据和研究思路。
[关键词] 黄连素；药性；功效；湿热证
[中图分类号] R285.5 [文献标识码] B [文章编号] 2095-0616（2012）21-52-02 Discussion on the medicinal properties and efficacy of berberine
ZHANG Yupei HAN Li YANG Qinhe KONG Yilin
1.Department of Traditional Chinese Medicine， School of Medicine， Jinan University， Guangzhou 510632， China；2.The First Affiliated Hospital of Jinan University， Guangzhou 510632， China；3.Guangdong Provincial Hospital of TCM， Guangzhou 510120， China
[Abstract] Berberine is the main active ingredient in Coptis，and it is consistent in medicinal properties ，efficacy and indications of syndromes compared with Coptis， especially in the
prevention and treatment of damp-heat syndrome research and clinical applications.Berberine has the effectiveness of heat-clearing and damp-drying therapy that closely related to the damp-heat syndrome. It is the the TCM theoretical basis for the clinical treatment of metabolic syndrome such as high blood pressure ， high blood sugar and lipid metabolism disorder syndrome. In this paper， clinical application of berberine as a breakthrough ，and to explore the intrinsic relationship between
berberine effectiveness of heat-clearing and damp-drying therapy with damp-heat syndrome. In order to clarify the medicinal properties and efficacy of berberine ， this study provides the TCM theoretical basis and research ideas.
[Key words] Berberine； Nature of a drug； Efficacy； Damp-heat syndrome
黄连素又称小檗碱，是从黄连、黄柏、三棵针或其他含有小檗碱的植物中提取的一种异喹啉类生物碱，临床上一直作为清热燥湿、泻火解毒、抗感染药物使用，具有价格便宜、抗菌谱较广、疗效确切和毒副作用小等特点。近年来在动物实验研究及临床疗效观察中发现黄连素在临床上还有许多新用途[1]，具有降血糖、降血压、调节脂质代谢、改善心功能和抗心律失常等作用，尤其在湿热性病证的治疗中临床效果满意。现结合相关文献及临床应用现状就黄连素